Reconstitution of hepatic uricase in planar lipid bilayer reveals a functional organic anion channel

Abstract

Rat renal proximal tubule cell membranes have been reported to contain uricase-like proteins that function as electrogenic urate transporters. Although uricase, per se, has only been detected within peroxisomes in rat liver (where it functions as an oxidative enzyme) this protein has been shown to function as a urate transport protein when inserted into… (More)
DOI: 10.1007/BF00238003

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