Reconstitution of cytomegalovirus specific T cells after pediatric allogeneic stem cell transplantation: results from a pilot study using a multi-allele CMV tetramer group.

@article{Koehl2008ReconstitutionOC,
  title={Reconstitution of cytomegalovirus specific T cells after pediatric allogeneic stem cell transplantation: results from a pilot study using a multi-allele CMV tetramer group.},
  author={Ulrike Koehl and E. Dirkwinkel and Margit Koenig and Stephanie Erben and Jan Soerensen and Peter Bader and Hans Wilhelm Doerr and Wolfgang Preiser and Eva Maria Weissinger and Th Klingebiel and Hans Martin and Thomas Lehrnbecher},
  journal={Klinische Padiatrie},
  year={2008},
  volume={220 6},
  pages={348-52}
}
BACKGROUND Recovery of cytomegalovirus (CMV)-specific T cell mediated immunity after allogeneic hematopoietic stem cell transplantation (SCT) is critical for protection against CMV disease. Tetramer-based technologies have been shown to be a sensitive tool in the enumeration of specific T cells, but have the disadvantage of HLA-restriction of the peptides. PATIENTS AND METHODS In this pilot study, we tested the feasibility of a panel of 6 CMV-specific tetrameric HLA/CMV-peptide complexes to… CONTINUE READING
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