Reconstitution of T-cell function after CD6-depleted allogeneic bone marrow transplantation.

  title={Reconstitution of T-cell function after CD6-depleted allogeneic bone marrow transplantation.},
  author={Robert J. Soiffer and Linda D. Bosserman and Christine Murray and Kenneth W. Cochran and Jamie Daley and Jorge Ritz},
  volume={75 10},
Patients who undergo allogeneic bone marrow transplantation (BMT) are clinically immunodeficient for a prolonged period after engraftment. In the present study, we examined immune function after BMT in a series of patients who had received HLA compatible sibling marrow grafts purged of T cells with anti-CD6 monoclonal antibody and complement. None of the patients in this analysis received immunomodulating agents and none had developed graft-versus-host disease (GVHD). Initially after BMT… CONTINUE READING
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