Reconstitution Properties of Thymus Stem Cells in Murine Fetal Liver

  title={Reconstitution Properties of Thymus Stem Cells in Murine Fetal Liver},
  author={Hilary J. Mckenna and Nicholas M. Birchall and James D. Watson},
  journal={Developmental Immunology},
  pages={247 - 256}
Injection of day-12 murine fetal liver cells into thymus lobes of Thy-1 congenic adult recipients results in a wave of thymocyte development. The kinetics of repopulation by donor cells reaches a peak after 20-25 days. The frequency of thymic stem cells (TSC) in day-12 fetal liver was estimated, by limit dilution, as 1 in 4 x 10(4) cells. Within 8 hr of injection into a thymus lobe, fetal liver TSC commit to T-cell development, losing stem-cell activity. When fetal liver cells are maintained in… CONTINUE READING


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