Reconstituting Organ-Level Lung Functions on a Chip

@article{Huh2010ReconstitutingOL,
  title={Reconstituting Organ-Level Lung Functions on a Chip},
  author={Dongeun Huh and Benjamin D. Matthews and Akiko Mammoto and Mart{\'i}n Montoya-Zavala and Hong Yuan Hsin and Donald E. Ingber},
  journal={Science},
  year={2010},
  volume={328},
  pages={1662 - 1668}
}
Here, we describe a biomimetic microsystem that reconstitutes the critical functional alveolar-capillary interface of the human lung. [...] Key Result This bioinspired microdevice reproduces complex integrated organ-level responses to bacteria and inflammatory cytokines introduced into the alveolar space. In nanotoxicology studies, this lung mimic revealed that cyclic mechanical strain accentuates toxic and inflammatory responses of the lung to silica nanoparticles.Expand
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Reversed-engineered human alveolar lung-on-a-chip model
  • Di Huang, Tingting Liu, +16 authors Yu Shrike Zhang
  • Medicine
    Proceedings of the National Academy of Sciences
  • 2021
TLDR
This study demonstrates a unique method for reconstitution of the functional human pulmonary alveoli in vitro, which is anticipated to pave the way for investigating relevant physiological and pathological events in the human distal lung.
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