Reconstituting Organ-Level Lung Functions on a Chip

@article{Huh2010ReconstitutingOL,
  title={Reconstituting Organ-Level Lung Functions on a Chip},
  author={D. Huh and B. Matthews and A. Mammoto and M. Montoya-Zavala and H. Hsin and D. Ingber},
  journal={Science},
  year={2010},
  volume={328},
  pages={1662 - 1668}
}
Here, we describe a biomimetic microsystem that reconstitutes the critical functional alveolar-capillary interface of the human lung. [...] Key Result This bioinspired microdevice reproduces complex integrated organ-level responses to bacteria and inflammatory cytokines introduced into the alveolar space. In nanotoxicology studies, this lung mimic revealed that cyclic mechanical strain accentuates toxic and inflammatory responses of the lung to silica nanoparticles.Expand
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References

SHOWING 1-10 OF 80 REFERENCES
In vitro analysis of a hepatic device with intrinsic microvascular-based channels
  • 149
Microscale culture of human liver cells for drug development
  • 984
  • PDF
Acoustically detectable cellular-level lung injury induced by fluid mechanical stresses in microfluidic airway systems
  • 336
  • PDF
...
1
2
3
4
5
...