Reconstituting Organ-Level Lung Functions on a Chip

@article{Huh2010ReconstitutingOL,
  title={Reconstituting Organ-Level Lung Functions on a Chip},
  author={Dongeun Huh and Benjamin D. Matthews and Akiko Mammoto and Mart{\'i}n Montoya-Zavala and Hong Yuan Hsin and Donald E. Ingber},
  journal={Science},
  year={2010},
  volume={328},
  pages={1662 - 1668}
}
Here, we describe a biomimetic microsystem that reconstitutes the critical functional alveolar-capillary interface of the human lung. [] Key Result This bioinspired microdevice reproduces complex integrated organ-level responses to bacteria and inflammatory cytokines introduced into the alveolar space. In nanotoxicology studies, this lung mimic revealed that cyclic mechanical strain accentuates toxic and inflammatory responses of the lung to silica nanoparticles.

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A second-generation lung-on-a-chip with an array of in vivo-like sized alveoli and a stretchable biological membrane allows mimicking in vivo functionality of the lung parenchyma at an unprecedented level and makes this model a more analogous tool for drug discovery, diseases modeling and precision medicine applications.

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...

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