Reconstituted human polyclonal plasma-derived secretory-like IgM and IgA maintain the barrier function of epithelial cells infected with an enteropathogen.

@article{Longet2014ReconstitutedHP,
  title={Reconstituted human polyclonal plasma-derived secretory-like IgM and IgA maintain the barrier function of epithelial cells infected with an enteropathogen.},
  author={St{\'e}phanie Longet and C{\'e}dric Vonarburg and Marius L{\"o}tscher and Sylvia M. Miescher and Adrian W. Zuercher and Blaise Corth{\'e}sy},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 31},
  pages={21617-26}
}
Intravenous administration of polyclonal and monoclonal antibodies has proven to be a clinically valid approach in the treatment, or at least relief, of many acute and chronic pathologies, such as infection, immunodeficiency, and a broad range of autoimmune conditions. Plasma-derived IgG or recombinant IgG are most frequently used for intravenous or subcutaneous administration, whereas a few IgM-based products are available as well. We have established recently that secretory-like IgA and IgM… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
By using polarized epithelial Caco-2 cell monolayers and Shigella flexneri as a model enteropathogen , we found that polyspecific plasma - derived SIgA and SIgM fulfill many protective functions , including dose - dependent recognition of the antigen via formation of aggregated immune complexes , reduction of bacterial infectivity , maintenance of epithelial cell integrity , and inhibition of proinflammatory cytokine / chemokine production by epithelial cells .
By using polarized epithelial Caco-2 cell monolayers and Shigella flexneri as a model enteropathogen , we found that polyspecific plasma - derived SIgA and SIgM fulfill many protective functions , including dose - dependent recognition of the antigen via formation of aggregated immune complexes , reduction of bacterial infectivity , maintenance of epithelial cell integrity , and inhibition of proinflammatory cytokine / chemokine production by epithelial cells .
All Topics