Reconstituted high-density lipoprotein neutralizes gram-negative bacterial lipopolysaccharides in human whole blood.

@article{Parker1995ReconstitutedHL,
  title={Reconstituted high-density lipoprotein neutralizes gram-negative bacterial lipopolysaccharides in human whole blood.},
  author={Thomas S. Parker and Daniel M. Levine and J C Chang and J A Laxer and Christopher C. Coffin and Albert L. Rubin},
  journal={Infection and immunity},
  year={1995},
  volume={63 1},
  pages={
          253-8
        }
}
We have tested hypotheses relating lipoprotein structure to function as measured by the relative ability to neutralize endotoxin by comparing natural human lipoproteins, a chemically defined form of reconstituted high-density lipoprotein (R-HDL), and a lipid emulsion (Intralipid). The human whole-blood system was used as an in vitro model of lipopolysaccharide (LPS) binding protein and CD14-dependent activation of cytokine production. When lipoproteins were compared on the basis of protein… CONTINUE READING

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