Reconstituted high-density lipoprotein attenuates platelet function in individuals with type 2 diabetes mellitus by promoting cholesterol efflux.

@article{Calkin2009ReconstitutedHL,
  title={Reconstituted high-density lipoprotein attenuates platelet function in individuals with type 2 diabetes mellitus by promoting cholesterol efflux.},
  author={Anna C. Calkin and Brian G. Drew and Akiko Ono and Stephen J Duffy and Michelle Gordon and Simone M Schoenwaelder and Dmitri D. Sviridov and Mark Emmanuel Cooper and Bronwyn A. Kingwell and Shaun P Jackson},
  journal={Circulation},
  year={2009},
  volume={120 21},
  pages={2095-104}
}
BACKGROUND Individuals with diabetes mellitus have an increased risk of cardiovascular disease and exhibit platelet hyperreactivity, increasing their resistance to antithrombotic therapies such as aspirin and clopidogrel. Reconstituted high-density lipoprotein (rHDL) has short-term beneficial effects on atherosclerotic plaques, but whether it can effectively reduce the reactivity of diabetic platelets is not known. METHODS AND RESULTS Individuals with type 2 diabetes mellitus were infused… CONTINUE READING
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