Reconsolidation of memory after its reactivation

  title={Reconsolidation of memory after its reactivation},
  author={Jean Przybyslawski and Susan Sara},
  journal={Behavioural Brain Research},

Reconsolidation of a well-learned instrumental memory.

It is shown that well-learned lever pressing in rats does undergo reconsolidation, which can be disrupted by systemic administration of the noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist (+)-5- methyl-10,11-dihydro-SH-dibenzo[a,d]cyclohepten-5,10-imine maleate (MK-801).

Anisomycin infused into the hippocampus fails to block "reconsolidation" but impairs extinction: the role of re-exposure duration.

The findings indicate that post-retrieval administration of anisomycin impairs subsequent retention performance only in the absence of extinction and that this impairment is temporary.

Reconsolidation after remembering an odor-reward association requires NMDA receptors.

It is concluded that NMDARs support a consolidation process taking place after memory reactivating, and animals receiving drug alone, in absence of reactivation, showed perfect retention.

Attenuation of Emotional and Nonemotional Memories after their Reactivation: Role of β Adrenergic Receptors

It is suggested that reactivation of memory triggers a β receptor-dependent cascade of intracellular events, recapitulating that which occurs during initial postacquisition consolidation, thus permitting reorganization of the existing memory as a function of new information in the retrieval environment.

Consolidation of Memory After its Reactivation: Involvement of β Noradrenergic Receptors in the Late Phase

The delayed amnesic action of timoloi suggests that β noradrenergic receptors and the cAMP cascade are implicated in the late phase of reprocessing of a remembered event.

Reconsolidation-induced memory persistence: Participation of late phase hippocampal ERK activation

Reactivation and Reconsolidation of Long-Term Memory in the CrabChasmagnathus: Protein Synthesis Requirement and Mediation by NMDA-Type Glutamatergic Receptors

Findings are consistent with those reported for vertebrates, with both showing that reactivation induces a recapitulation of the postacquisition cascade of intracellular events.



NMDA antagonist MK-801 impairs acquisition but not performance of spatial working and reference memory

The results show that functioning NMDA receptors are necessary for learning spatial WM and RM tasks, but not for performing WM or RM tasks after training, and imply that two mechanisms may be required for storing relational memory: an NMDA-dependent mechanism for long-term storage of spatial representations, and a second, non-NMDA mechanism for operating upon those representations.

Memory Formation in Day‐old Chicks Requires NMDA but not Non‐NMDA Glutamate Receptors

Results are interpreted as pointing to a requirement for NMDA, but not kainate or quisqualate, receptor activation as an early enabling event in the biochemical cascade required for long‐term memory formation for passive avoidance in the chick.

MK-801 and AP5 impair acquisition, but not retention, of the Morris milk maze

Passive avoidance behavior in rats after electroconvulsive shock: facilitative effect of response retardation.

Electroconvulsive shock effects are taken as evidence that ECS effects are not on memory storage but on the capacity of the animal to organize information effectively and quickly in order to produce an adaptive response.

Retrograde Amnesia Produced by Electroconvulsive Shock after Reactivation of a Consolidated Memory Trace

Rats had a memory loss of a fear response when they received an electroconvulsive shock 24 hours after the fear-conditioning trial and preceded by a brief presentation of the conditioned stimulus, which throws doubt on the assertion that electro Convulsive shock exerts a selective amnesic effect on recently acquired memories.

Amnesic effect of the novel anticonvulsant MK-801

Delayed development of amnestic behavior after hypoxia.

  • S. Sara
  • Psychology, Biology
    Physiology & behavior
  • 1974

Excitatory amino acids in synaptic transmission in the Schaffer collateral‐commissural pathway of the rat hippocampus.

Results indicate that the synaptic receptor in the Schaffer collateral‐commissural pathway may be of the kainate or quisqualate type and although NMA receptors do not appear to be involved in normal synaptic transmission in this pathway they may play a role in synaptic plasticity.