Reconsidering the effects of monosodium glutamate: A literature review

  title={Reconsidering the effects of monosodium glutamate: A literature review},
  author={Matthew Freeman},
  journal={Journal of the American Academy of Nurse Practitioners},
  • M. Freeman
  • Published 1 October 2006
  • Medicine
  • Journal of the American Academy of Nurse Practitioners
Purpose: This article reviews the literature from the past 40 years of research related to monosodium glutamate (MSG) and its ability to trigger a migraine headache, induce an asthma exacerbation, or evoke a constellation of symptoms described as the “Chinese restaurant syndrome.” Data sources: Literature retrieved by a search using PubMed, Medline, Lexis‐Nexus, and Infotrac to review articles from the past 40 years. Conclusions: MSG has a widespread reputation for eliciting a variety of… 

Monosodium glutamate avoidance for chronic asthma in adults and children.

There is no evidence to support the avoidance of MSG in adults with chronic asthma, but as data were limited, this review cannot provide a reliable evidence base for determining whether MSG avoidance is a worthwhile strategy.

Monosodium glutamate: Review on clinical reports

This study aimed to shed light on the available literature from last 25 years about different clinical trials which had been carried out on animal and human models regarding possible effects of monosodium glutamate regarding increased hunger, food intake, and obesity in human subjects.

A review of the alleged health hazards of monosodium glutamate.

Critical analysis of existing literature establishes that many of the reported negative health effects of MSG have little relevance for chronic human exposure and are poorly informative as they are based on excessive dosing that does not meet with levels normally consumed in food products.


It is safe to conclude that MSG has the potential to create several health hazards and thus advocates strict guidelines and mass awareness regarding its use.

Update on food safety of monosodium l-glutamate (MSG).

  • H. Henry-Unaeze
  • Biology, Medicine
    Pathophysiology : the official journal of the International Society for Pathophysiology
  • 2017

Genotoxicity of Monosodium Glutamate: A Review on its Causes, Consequences and Prevention

The data available on Google scholar, NCBI, PUBMED, EMBASE, Wang fang databases, meta-analysis and Web of Science indicated that long-term consumption of MSG is associated with metabolic diseases, neurological and reproductive organ defects and MSG has the ability to induce genotoxicity.

Mini Review About Monosodium Glutamate

A need of full comprehension about MSG is necessary to give more attention in studying it, and advantage in the development of analysis methods and technical equipments should be exploited to obtain higher accuracy result.

Pathogenesis of migraine: from neurotransmitters to neuromodulators and beyond

It is believed that migraine attacks derive from a top-down dysfunctional process that initiates in a hyperexcitable and hypoenergetic brain in the frontal lobe and downstream in abnormally activated nuclei of the pain matrix.

Pathogenesis of Migraine: Role of Neuromodulators

It is proposed that migraine attacks derive from a top‐down dysfunctional process that initiates in the frontal lobe in a hyperexcitable and hypoenergetic brain, thereafter progressing downstream resulting in abnormally activated nuclei of the pain matrix.

Glutamate - a multifaceted molecule: endogenous neurotransmitter, controversial food additive, design compound for anti-cancer drugs. A critical appraisal.




Review of alleged reaction to monosodium glutamate and outcome of a multicenter double-blind placebo-controlled study.

Large doses of MSG given without food may elicit more symptoms than a placebo in individuals who believe that they react adversely to MSG, but the frequency of the responses was low and the responses reported were inconsistent and were not reproducible.

Monosodium glutamate-induced asthma: study of the potential risk of 30 asthmatics and review of the literature.

It is concluded that a very small subset of patients with intrinsic asthma might present with an intolerance to MSG if high doses are consumed.

Monosodium glutamate sensitivity in asthma.

Monosodium L-glutamate-induced asthma.

Monosodium Glutamate and the Chinese Restaurant Syndrome

IT has been suggested1–4 that monosodium glutamate (MSG) is responsible for the “Chinese restaurant syndrome”—a burning sensation in the back of the neck spreading to the forearms and to the anterior

The Chinese restaurant syndrome: an anecdote revisited.

  • R. Kenney
  • Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1986