Reconsidering the Sporulation Characteristics of Hypervirulent Clostridium difficile BI/NAP1/027

@inproceedings{Burns2011ReconsideringTS,
  title={Reconsidering the Sporulation Characteristics of Hypervirulent Clostridium difficile BI/NAP1/027},
  author={David A. Burns and Daniela Heeg and Stephen T. Cartman and Nigel P. Minton},
  booktitle={PloS one},
  year={2011}
}
Clostridium difficile is the leading cause of antibiotic-associated diarrhoea and a major burden to healthcare services worldwide. In recent years, C. difficile strains belonging to the BI/NAP1/027 type have become highly represented among clinical isolates. These so-called 'hypervirulent' strains are associated with outbreaks of increased disease severity, higher relapse rates and an expanded repertoire of antibiotic resistance. Spores, formed during sporulation, play a pivotal role in disease… CONTINUE READING
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