Reconsidering anhedonia in depression: lessons from translational neuroscience.

  title={Reconsidering anhedonia in depression: lessons from translational neuroscience.},
  author={Michael Tilghman Treadway and David H. Zald},
  journal={Neuroscience and biobehavioral reviews},
  volume={35 3},
Anhedonia is a core symptom of major depressive disorder (MDD), the neurobiological mechanisms of which remain poorly understood. Despite decades of speculation regarding the role of dopamine (DA) in anhedonic symptoms, empirical evidence has remained elusive, with frequent reports of contradictory findings. In the present review, we argue that this has resulted from an underspecified definition of anhedonia, which has failed to dissociate between consummatory and motivational aspects of reward… CONTINUE READING
Highly Influential
This paper has highly influenced 27 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
285 Citations
332 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 285 extracted citations


Publications referenced by this paper.
Showing 1-10 of 332 references

Similar Papers

Loading similar papers…