Reconsider Alzheimer's disease by the ‘calpain–cathepsin hypothesis’—A perspective review

@article{Yamashima2013ReconsiderAD,
  title={Reconsider Alzheimer's disease by the ‘calpain–cathepsin hypothesis’—A perspective review},
  author={T. Yamashima},
  journal={Progress in Neurobiology},
  year={2013},
  volume={105},
  pages={1-23}
}
  • T. Yamashima
  • Published 2013
  • Medicine, Biology
  • Progress in Neurobiology
Alzheimer's disease (AD) is characterized by slowly progressive neuronal death, but its molecular cascade remains elusive for over 100 years. Since accumulation of autophagic vacuoles (also called granulo-vacuolar degenerations) represents one of the pathologic hallmarks of degenerating neurons in AD, a causative connection between autophagy failure and neuronal death should be present. The aim of this perspective review is at considering such underlying mechanism of AD that age-dependent… Expand
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