Reconfiguring the architectures of cationic helical polypeptides to control non-viral gene delivery.

@article{Yin2013ReconfiguringTA,
  title={Reconfiguring the architectures of cationic helical polypeptides to control non-viral gene delivery.},
  author={Lichen Yin and Ziyuan Song and Kyung Hoon Kim and Nan Zheng and Haoyu Tang and Hua Lu and Nathan P. Gabrielson and Jianjun Cheng},
  journal={Biomaterials},
  year={2013},
  volume={34 9},
  pages={2340-9}
}
Poly(γ-4-((2-(piperidin-1-yl)ethyl)aminomethyl)benzyl-l-glutamate) (PPABLG), a cationic helical polypeptide, has been recently developed by us as an effective non-viral gene delivery vector. In attempts to elucidate the effect of molecular architecture on the gene delivery efficiencies and thereby identify a potential addition to PPABLG with improved transfection efficiency and reduced cytotoxicity, we synthesized PEG-PPABLG copolymers with diblock, triblock, graft, and star-shaped… CONTINUE READING

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