Reconfiguration of the pontomedullary respiratory network: a computational modeling study with coordinated in vivo experiments.

@article{Rybak2008ReconfigurationOT,
  title={Reconfiguration of the pontomedullary respiratory network: a computational modeling study with coordinated in vivo experiments.},
  author={Ilya A. Rybak and R. O'Connor and A. Ross and Natalia A. Shevtsova and Sabine Nuding and Lauren S. Segers and R. Shannon and Thomas E. Dick and Witali L. Dunin-Barkowski and John M. Orem and Irene C. Solomon and K. F. Morris and B. G. Lindsey},
  journal={Journal of neurophysiology},
  year={2008},
  volume={100 4},
  pages={
          1770-99
        }
}
A large body of data suggests that the pontine respiratory group (PRG) is involved in respiratory phase-switching and the reconfiguration of the brain stem respiratory network. However, connectivity between the PRG and ventral respiratory column (VRC) in computational models has been largely ad hoc. We developed a network model with PRG-VRC connectivity inferred from coordinated in vivo experiments. Neurons were modeled in the "integrate-and-fire" style; some neurons had pacemaker properties… 

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