Reconciled rat and human metabolic networks for comparative toxicogenomics and biomarker predictions

  title={Reconciled rat and human metabolic networks for comparative toxicogenomics and biomarker predictions},
  author={Edik M. Blais and Kristopher D. Rawls and Bonnie V. Dougherty and Zhuo I. Li and Glynis L. Kolling and Ping Ye and Anders Wallqvist and Jason A. Papin},
  booktitle={Nature communications},
The laboratory rat has been used as a surrogate to study human biology for more than a century. Here we present the first genome-scale network reconstruction of Rattus norvegicus metabolism, iRno, and a significantly improved reconstruction of human metabolism, iHsa. These curated models comprehensively capture metabolic features known to distinguish rats from humans including vitamin C and bile acid synthesis pathways. After reconciling network differences between iRno and iHsa, we integrate… CONTINUE READING
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