Recommended use of morphine in neonates, infants and children based on a literature review: Part 1--Pharmacokinetics.

@article{Kart1997RecommendedUO,
  title={Recommended use of morphine in neonates, infants and children based on a literature review: Part 1--Pharmacokinetics.},
  author={T{\"u}rkay Kart and Lona Louring Christrup and Magnhild Rasmussen},
  journal={Paediatric anaesthesia},
  year={1997},
  volume={7 1},
  pages={5-11}
}
The English language literature has been reviewed in order to evaluate the present knowledge on morphine's metabolism and pharmacokinetics in children. The majority of preterm neonates are capable of glucuronidating morphine, but birth weight; gestational and postnatal age influence the glucuronidation capability. Term neonates, infants, and children are able to produce morphine glucuronides. For the reported pharmacokinetics parameters a meta-analysis was made; volume of distribution… CONTINUE READING

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