Recommended joint and meta-analysis strategies for case-control association testing of single low-count variants.

@article{Ma2013RecommendedJA,
  title={Recommended joint and meta-analysis strategies for case-control association testing of single low-count variants.},
  author={Clement Ma and Tom Blackwell and Michael Boehnke and Laura J. Scott},
  journal={Genetic epidemiology},
  year={2013},
  volume={37 6},
  pages={539-50}
}
In genome-wide association studies of binary traits, investigators typically use logistic regression to test common variants for disease association within studies, and combine association results across studies using meta-analysis. For common variants, logistic regression tests are well calibrated, and meta-analysis of study-specific association results is only slightly less powerful than joint analysis of the combined individual-level data. In recent sequencing and dense chip based… CONTINUE READING
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