Recommendations for validating estrogen and progesterone receptor immunohistochemistry assays.

@article{Fitzgibbons2010RecommendationsFV,
  title={Recommendations for validating estrogen and progesterone receptor immunohistochemistry assays.},
  author={Patrick L. Fitzgibbons and Douglas L. Murphy and M Elizabeth Hale Hammond and Donald Craig Allred and Paul N. Valenstein},
  journal={Archives of pathology & laboratory medicine},
  year={2010},
  volume={134 6},
  pages={930-5}
}
CONTEXT Estrogen receptor and progesterone receptor status is assessed on all newly diagnosed, invasive breast carcinomas and in recurrences to determine patient eligibility for hormonal therapy, but 10% to 20% of estrogen receptor and progesterone receptor test results are discordant when tested in multiple laboratories. OBJECTIVE To define the analytic (technical) validation requirements for estrogen receptor and progesterone receptor immunohistochemistry assays used to select patients for… CONTINUE READING
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