Recommendations for Management of Clinically Significant Drug-Drug Interactions With Statins and Select Agents Used in Patients With Cardiovascular Disease: A Scientific Statement From the American Heart Association

@article{Wiggins2016RecommendationsFM,
  title={Recommendations for Management of Clinically Significant Drug-Drug Interactions With Statins and Select Agents Used in Patients With Cardiovascular Disease: A Scientific Statement From the American Heart Association},
  author={Barbara S. Wiggins and Joseph J. Saseen and Robert Lee Page and Brent N. Reed and Kevin B. Sneed and John B. Kostis and David E. Lanfear and Salim S. Virani and Pamela Bowe Morris},
  journal={Circulation},
  year={2016},
  volume={134},
  pages={e468–e495}
}
A drug-drug interaction (DDI) is a pharmacokinetic or pharmacological influence of 1 medication on another that differs from the known or anticipated effects of each agent alone.1 A DDI may result in a change in either drug efficacy or drug toxicity for 1 or both of the interacting medications.2 Pharmacokinetic DDIs result in altered absorption, distribution, metabolism, or excretion of a medication. [] Key Method Interpreting this information …

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