Recommendations for HLA‐B*15:02 and HLA‐A*31:01 genetic testing to reduce the risk of carbamazepine‐induced hypersensitivity reactions

@article{Amstutz2014RecommendationsFH,
  title={Recommendations for HLA‐B*15:02 and HLA‐A*31:01 genetic testing to reduce the risk of carbamazepine‐induced hypersensitivity reactions},
  author={U Amstutz and Neil H. Shear and Michael Rieder and Soomi Hwang and Vincent Fung and Hidefumi Nakamura and Mary B. Connolly and Shinya Ito and Bruce C. Carleton},
  journal={Epilepsia},
  year={2014},
  volume={55}
}
To systematically review evidence on genetic risk factors for carbamazepine (CBZ)–induced hypersensitivity reactions (HSRs) and provide practice recommendations addressing the key questions: (1) Should genetic testing for HLA‐B*15:02 and HLA‐A*31:01 be performed in patients with an indication for CBZ therapy to reduce the occurrence of CBZ‐induced HSRs? (2) Are there subgroups of patients who may benefit more from genetic testing for HLA‐B*15:02 or HLA‐A*31:01 compared to others? (3) How should… Expand
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TLDR
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TLDR
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HLA-A*31:01 and carbamazepine-induced DRESS syndrom in a sample of North African population
PURPOSE Drug rash with eosinophilia and systemic symptoms (DRESS) is a serious adverse drug reaction. Carbamazepine is the most common causes of this syndrome. The HLA-A*31:01 allele has been shownExpand
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TLDR
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