Recommendations for HLA‐B*15:02 and HLA‐A*31:01 genetic testing to reduce the risk of carbamazepine‐induced hypersensitivity reactions

@article{Amstutz2014RecommendationsFH,
  title={Recommendations for HLA‐B*15:02 and HLA‐A*31:01 genetic testing to reduce the risk of carbamazepine‐induced hypersensitivity reactions},
  author={U. Amstutz and N. Shear and M. Rieder and Soomi Hwang and Vincent Fung and H. Nakamura and M. Connolly and S. Ito and B. Carleton},
  journal={Epilepsia},
  year={2014},
  volume={55}
}
  • U. Amstutz, N. Shear, +6 authors B. Carleton
  • Published 2014
  • Medicine
  • Epilepsia
  • To systematically review evidence on genetic risk factors for carbamazepine (CBZ)–induced hypersensitivity reactions (HSRs) and provide practice recommendations addressing the key questions: (1) Should genetic testing for HLA‐B*15:02 and HLA‐A*31:01 be performed in patients with an indication for CBZ therapy to reduce the occurrence of CBZ‐induced HSRs? (2) Are there subgroups of patients who may benefit more from genetic testing for HLA‐B*15:02 or HLA‐A*31:01 compared to others? (3) How should… CONTINUE READING
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