Recombinogenic phenotype of human activation-induced cytosine deaminase.

  title={Recombinogenic phenotype of human activation-induced cytosine deaminase.},
  author={Vladimir Poltoratsky and Samuel H. Wilson and T. A. Kunkel and Youri I. Pavlov},
  journal={Journal of immunology},
  volume={172 7},
Class switch recombination, gene conversion, and somatic hypermutation that diversify rearranged Ig genes to produce various classes of high affinity Abs are dependent on the enzyme activation-induced cytosine deaminase (AID). Evidence suggests that somatic hypermutation is due to error-prone DNA repair that is initiated by AID-mediated deamination of cytosine in DNA, whereas the mechanism by which AID controls recombination remains to be elucidated. In this study, using a yeast model system… CONTINUE READING