Recombinational exchanges at the capsular polysaccharide biosynthetic locus lead to frequent serotype changes among natural isolates of Streptococcus pneumoniae.

@article{Coffey1998RecombinationalEA,
  title={Recombinational exchanges at the capsular polysaccharide biosynthetic locus lead to frequent serotype changes among natural isolates of Streptococcus pneumoniae.},
  author={Tracey J. Coffey and Mark C. Enright and Michael Daniels and Judy K. Morona and Renato Morona and Waleria Hryniewicz and James C Paton and Brian G. Spratt},
  journal={Molecular microbiology},
  year={1998},
  volume={27 1},
  pages={73-83}
}
Serotype 19F variants of the major Spanish multiresistant serotype 23F clone of Streptococcus pneumoniae have been proposed to have arisen by recombinational exchanges at the capsular biosynthetic locus. Members of the Spanish multiresistant serotype 23F clone and the serotype 19F variants were confirmed to be essentially identical in overall genotype, as they were indistinguishable by REP-PCR, and had identical sequences at three polymorphic housekeeping genes. Eight serotype 19F variants were… CONTINUE READING
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