Recombination studies of lactose nonfermenting mutants of Escherichia coli K-12.

@article{Cook1962RecombinationSO,
  title={Recombination studies of lactose nonfermenting mutants of Escherichia coli K-12.},
  author={Amy Cook and Joshua Lederberg},
  journal={Genetics},
  year={1962},
  volume={47},
  pages={
          1335-53
        }
}
T HE fermentation of lactose is a diagnostic character of Escherichia coli; however, nonfermenting mutants can readily be obtained. These mutants may show losses or changes in the accumulation of lactose or other p-galactosides in the cell, or in the formation or activity of the enzyme, ,8-galactosidase, which splits lactose to the constituent monosaccharides. Such mutants have played an important part in the analysis of gene action (JACOB and MONOD 1961) . A comprehensive model of the action… CONTINUE READING

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