Recombination signal sequence binding protein Jkappa is constitutively bound to the NF-kappaB site of the interleukin-6 promoter and acts as a negative regulatory factor.

@article{Plaisance1997RecombinationSS,
  title={Recombination signal sequence binding protein Jkappa is constitutively bound to the NF-kappaB site of the interleukin-6 promoter and acts as a negative regulatory factor.},
  author={St{\'e}phane Plaisance and Wim Vanden Berghe and Elke Boone and Walter Fiers and Guy Haegeman},
  journal={Molecular and cellular biology},
  year={1997},
  volume={17 7},
  pages={3733-43}
}
Analysis by electrophoretic mobility shift assays (EMSA) of the different proteins associated with the kappaB sequence of the interleukin-6 (IL-6) promoter (IL6-kappaB) allowed us to detect a specific complex formed with the recombination signal sequence binding protein Jkappa (RBP-Jkappa). Single-base exchanges within the oligonucleotide sequence defined the critical base pairs involved in the interaction between RBP-Jkappa and the IL6-kappaB motif. Binding analysis suggests that the amount of… CONTINUE READING

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