Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.

@article{Nakayama1987RecombinationOT,
  title={Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.},
  author={Kohzo Nakayama and Mayumi Nonaka and Shigeru Yokoyama and Y D Yeul and Sa-nga Pattanakitsakul and Minoru Takahashi},
  journal={Journal of immunology},
  year={1987},
  volume={138 2},
  pages={620-7}
}
In most mouse strains, expression of a gene encoding sex-limited protein (Slp), an isotype of the fourth component of complement (C4), is induced by testosterone, or the gene is not expressed at all; however, in some wild-derived strains carrying H-2w7, H-2w16, or H-2w19 haplotype, Slp is expressed constitutively in the same way as C4. To examine the structural basis for the testosterone-independent expression of Slp, 41 overlapping clones together encoding the S region were isolated from C3H… CONTINUE READING