Recombination of retrotransposon and exogenous RNA virus results in nonretroviral cDNA integration.

@article{Geuking2009RecombinationOR,
  title={Recombination of retrotransposon and exogenous RNA virus results in nonretroviral cDNA integration.},
  author={Markus B Geuking and Jacqueline Weber and Marie Dewannieux and Elieser Gorelik and T. Heidmann and Hans Hengartner and Rolf Martin Zinkernagel and Lars Hangartner},
  journal={Science},
  year={2009},
  volume={323 5912},
  pages={393-6}
}
Retroviruses have the potential to acquire host cell-derived genetic material during reverse transcription and can integrate into the genomes of larger, more complex DNA viruses. In contrast, RNA viruses were believed not to integrate into the host's genome under any circumstances. We found that illegitimate recombination between an exogenous nonretroviral RNA virus, lymphocytic choriomeningitis virus, and the endogenous intracisternal A-type particle (IAP) retrotransposon occurred and led to… CONTINUE READING