Recombination-dependent mtDNA partitioning: in vivo role of Mhr1p to promote pairing of homologous DNA.

@article{Ling2002RecombinationdependentMP,
  title={Recombination-dependent mtDNA partitioning: in vivo role of Mhr1p to promote pairing of homologous DNA.},
  author={F. H. Ling and Takehiko Shibata},
  journal={The EMBO journal},
  year={2002},
  volume={21 17},
  pages={4730-40}
}
Yeast mhr1-1 was isolated as a defective mutation in mitochondrial DNA (mtDNA) recombination. About half of mhr1-1 cells lose mtDNA during growth at a higher temperature. Here, we show that mhr1-1 exhibits a defect in the partitioning of nascent mtDNA into buds and is a base-substitution mutation in MHR1 encoding a mitochondrial matrix protein. We found that the Mhr1 protein (Mhr1p) has activity to pair single-stranded DNA and homologous double-stranded DNA to form heteroduplex joints in vitro… CONTINUE READING

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