Recombination between genes encoding major outer surface proteins A and B of Borrelia burgdorferi.

@article{Rosa1992RecombinationBG,
  title={Recombination between genes encoding major outer surface proteins A and B of Borrelia burgdorferi.},
  author={Patricia A Rosa and Tom G. Schwan and Daniel B. Hogan},
  journal={Molecular microbiology},
  year={1992},
  volume={6 20},
  pages={
          3031-40
        }
}
Borrelia burgdorferi causes Lyme disease, a multisystem illness that can persist in humans for many years. We describe recombination between homologous genes encoding the major outer surface proteins (Osps) A and B of B. burgdorferi which both deletes osp gene sequences and creates chimaeric gene fusions. Recombinant osp genes occur in multiple strains and encode unique proteins that lack some characteristic Osp epitopes. Antigenic variation in Osp through recombination may be relevant to the… CONTINUE READING

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