Recombination between DNA repeats in yeast hpr1delta cells is linked to transcription elongation.

@article{Prado1997RecombinationBD,
  title={Recombination between DNA repeats in yeast hpr1delta cells is linked to transcription elongation.},
  author={F{\'e}lix Prado and Jos{\'e} Ignacio Piruat and Andr{\'e}s Aguilera},
  journal={The EMBO journal},
  year={1997},
  volume={16 10},
  pages={2826-35}
}
The induction of recombination by transcription activation has been documented in prokaryotes and eukaryotes. Unwinding of the DNA duplex, disruption of chromatin structure or changes in local supercoiling associated with transcription can be indirectly responsible for the stimulation of recombination. Here we provide genetic and molecular evidence for a specific mechanism of stimulation of recombination by transcription. We show that the induction of deletions between repeats in hpr1delta… CONTINUE READING