Recombination affects accumulation of damaging and disease-associated mutations in human populations

@article{Hussin2015RecombinationAA,
  title={Recombination affects accumulation of damaging and disease-associated mutations in human populations},
  author={Julie G. Hussin and Alan Hodgkinson and Youssef Idaghdour and Jean-Christophe Grenier and Jean-Philippe Goulet and Elias Gbeha and Elodie Hip-Ki and Philip Awadalla},
  journal={Nature Genetics},
  year={2015},
  volume={47},
  pages={400-404}
}
Many decades of theory have demonstrated that, in non-recombining systems, slightly deleterious mutations accumulate non-reversibly, potentially driving the extinction of many asexual species. Non-recombining chromosomes in sexual organisms are thought to have degenerated in a similar fashion; however, it is not clear the extent to which damaging mutations accumulate along chromosomes with highly variable rates of crossing over. Using high-coverage sequencing data from over 1,400 individuals in… Expand
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