Recombination Proteins Mediate Meiotic Spatial Chromosome Organization and Pairing

@article{Storlazzi2010RecombinationPM,
  title={Recombination Proteins Mediate Meiotic Spatial Chromosome Organization and Pairing},
  author={Aurora Storlazzi and Silvana Gargano and Gwenael Ruprich-Robert and Matthieu Falque and Michelle David and Nancy E Kleckner and Denise Zickler},
  journal={Cell},
  year={2010},
  volume={141},
  pages={94-106}
}
Meiotic chromosome pairing involves not only recognition of homology but also juxtaposition of entire chromosomes in a topologically regular way. Analysis of filamentous fungus Sordaria macrospora reveals that recombination proteins Mer3, Msh4, and Mlh1 play direct roles in all of these aspects, in advance of their known roles in recombination. Absence of Mer3 helicase results in interwoven chromosomes, thereby revealing the existence of features that specifically ensure "entanglement avoidance… CONTINUE READING

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