148 Citations
Reduced efficacy of selection in regions of the Drosophila genome that lack crossing over
- BiologyGenome Biology
- 2006
All of the patterns observed are consistent with a severe reduction in the efficacy of selection in the absence of crossing over, resulting in the accumulation of deleterious mutations in these regions.
The Many Landscapes of Recombination in Drosophila melanogaster
- BiologyPLoS genetics
- 2012
This is the first integrated high-resolution description of genomic and population variation in recombination, which also distinguishes between the two outcomes of meiotic recombination: crossing over (CO) and gene conversion (GC).
Reduced Effectiveness of Selection Caused by a Lack of Recombination
- BiologyCurrent Biology
- 2009
Similar efficacies of selection shape mitochondrial and nuclear genes in Drosophila melanogaster and Homo sapiens
- BiologybioRxiv
- 2015
Despite a smaller Ne, mitochondrial loci of both flies and humans appear to experience similar efficacies of selection as do loci in the recombining nuclear genome.
Recombination yet inefficient selection along the Drosophila melanogaster subgroup's fourth chromosome.
- BiologyMolecular biology and evolution
- 2010
Despite there being recombination, there is strong evidence that its frequency is low enough to have rendered selection relatively inefficient and the signatures of relaxed constraint can be detected at both the level of polymorphism and divergence.
THE EFFECT OF DELETERIOUS MUTATIONS AND AGE ON RECOMBINATION IN DROSOPHILA MELANOGASTER
- BiologyEvolution; international journal of organic evolution
- 2012
It is found that deleterious alleles not only alter the rate but also the pattern of recombination, and the differences among genotypes or among age classes are large enough to add substantial noise to genetic mapping experiments that do not consider these sources of variation.
Similar Efficacies of Selection Shape Mitochondrial and Nuclear Genes in Both Drosophila melanogaster and Homo sapiens
- BiologyG3: Genes, Genomes, Genetics
- 2015
Mitochondrial loci of both flies and humans appear to experience similar efficacies of purifying selection as do loci in the recombining nuclear genome, and the neutrality index, a measure of the excess of nonsynonymous polymorphism relative to the neutral expectation, is only weakly significantly different between mitochondrial and nuclear loci.
Local effects of limited recombination in Drosophila
- Biology
- 2010
A computer simulation approach is developed to investigate the local consequences of linked selection on estimates of selection and the proportion of adaptive substitutions using the McDonald-Kreitman framework, suggesting that even a high level of recombination is unlikely to remove all the effects of linked Selection.
Molecular Evolution in Nonrecombining Regions of the Drosophila melanogaster Genome
- BiologyGenome biology and evolution
- 2012
The patterns observed are consistent with a reduction in the efficacy of selection in all regions of the genome of D. melanogaster that lack crossing-over, as a result of the effects of enhanced Hill–Robertson interference.
Genomic Variation in Natural Populations of Drosophila melanogaster
- BiologyGenetics
- 2012
This report of independent genome sequences of two natural populations of Drosophila melanogaster provides unique insight into forces shaping genomic polymorphism and divergence, suggesting many targets of directional selection are shared between these species.
References
SHOWING 1-10 OF 70 REFERENCES
Adaptation shapes patterns of genome evolution on sexual and asexual chromosomes in Drosophila
- BiologyNature Genetics
- 2003
The limits to natural selection in an asexual genome are illustrated by comparing patterns of genome evolution in a 40-kb gene-rich region on homologous neo-sex chromosomes of Drosophila miranda.
Reduced natural selection associated with low recombination in Drosophila melanogaster.
- BiologyMolecular biology and evolution
- 1993
In analyses of 385 D. melanogaster loci, it is found that codon bias is reduced in regions of low recombination (i.e., near centromeres and telomeres and on the fourth chromosome), and this model of varying selection intensity is linked to the population-genetics prediction that the effectiveness of natural selection is decreased under reduced recombination.
Levels of naturally occurring DNA polymorphism correlate with recombination rates in D. melanogaster
- BiologyNature
- 1992
For 20 gene regions from across the genome, the amount of nucleotide diversity in natural populations of D. melanogaster is positively correlated with the regional rate of recombination, and it is suggested that the correlation may result from genetic hitch-hiking associated with the fixation of advantageous mutants.
Linkage limits the power of natural selection in Drosophila
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 2002
The rate of protein adaptation is reduced in regions of low recombination, and evolution at strongly selected amino acid sites interferes with optimal codon usage at weakly selected, tightly linked synonymous sites, suggesting that linkage limits the rate and degree of adaptation even in recombining genomes.
Regions of lower crossing over harbor more rare variants in African populations of Drosophila melanogaster.
- BiologyGenetics
- 2001
It is shown that, in African populations, a summary of the frequency spectrum of polymorphic mutations is positively correlated with the meiotic rate of crossing over, and hitchhiking due to the recurrent fixation of advantageous variants is the most plausible explanation for the data.
Background selection and patterns of genetic diversity in Drosophila melanogaster.
- BiologyGenetical research
- 1996
It is shown that many features of the observed relations between chromosomal location and level of genetic diversity in D. melanogaster can be explained by background selection, especially if the weak selective forces acting on transposable elements are taken into account.
Deleterious mutation accumulation in organelle genomes
- BiologyGenetica
- 2004
The authors' results suggest an almost universal increase in the fixation probabilities of mildly deleterious mutations arising in mitochondrial and chloroplast genomes relative to those arising in the recombining nuclear genome.
The cost of inbreeding in Arabidopsis
- Biology, Environmental ScienceNature
- 2002
In a comparison of amino-acid replacements amongspecies of the mustard weed Arabidopsis with those among species of the fruitfly Drosophila, it is found that there is evidence for predominantly beneficial gene substitutions but predominantly detrimental substitutions inArabidopsis, corroborating a prediction of population genetics theory that species with a high frequency of inbreeding are less efficient in eliminating deleterious mutations.
Reduced adaptation of a non-recombining neo-Y chromosome
- BiologyNature
- 2002
Sex chromosomes are generally believed to have descended from a pair of homologous autosomes. Suppression of recombination between the ancestral sex chromosomes led to the genetic degeneration of the…
Effects of linkage on rates of molecular evolution.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 1988
Computer simulations and a mathematical argument show that complete linkage to either advantageous or deleterious mutations does not affect the substitution of selectively neutral mutations, However, the simulations show that linkage to selected background mutations decreases the rate of fixation of advantageous mutations and increases the rateof fixation of detrimental mutations.