Recombination‐activating gene proteins: more regulation, please

@article{Sadofsky2004RecombinationactivatingGP,
  title={Recombination‐activating gene proteins: more regulation, please},
  author={Moshe J. Sadofsky},
  journal={Immunological Reviews},
  year={2004},
  volume={200}
}
  • M. Sadofsky
  • Published 1 August 2004
  • Biology
  • Immunological Reviews
Summary:  Developing B and T cells assemble gene segments in order to create the variable regions of immunoglobulin and T‐cell receptors required by our adaptive immune response. The chemistry of this recombination pathway requires a specific nuclease and a more general repair pathway for double‐strand breaks. A complex of the recombination‐activating gene 1 (RAG1) and RAG2 proteins provides the nuclease activity. In fact, RAG1 and RAG2 probably coordinate many steps involving the coding and… 
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TLDR
Advances that have been made in understanding how V(D)J recombination at the IgH locus is controlled are summarized and important areas for future investigation are discussed.
Cytosines, but Not Purines, Determine Recombination Activating Gene (RAG)-induced Breaks on Heteroduplex DNA Structures
TLDR
The mechanism of RAG cleavage described here could explain facets of chromosomal rearrangements specific to lymphoid tissues leading to genomic instability.
Identification of RAG-like transposons in protostomes suggests their ancient bilaterian origin
TLDR
The findings raise the possibility that the RAGL transposon arose earlier in evolution than previously thought, either in an early bilaterian or prior to the divergence of bilaterians and non-bilaterians, and alter the understanding of the evolutionary history of this important group of transposons.
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