Recombinants are isolated at high frequency following in vivo mixed ocular infection with two avirulent herpes simplex virus type 1 strains

@article{Kintner1995RecombinantsAI,
  title={Recombinants are isolated at high frequency following in vivo mixed ocular infection with two avirulent herpes simplex virus type 1 strains},
  author={Randall L Kintner and Robert William Allan and Curtis R. Brandt},
  journal={Archives of Virology},
  year={1995},
  volume={140},
  pages={231-244}
}
Mixed infections with different strains of herpes simplex virus type 1 (HSV-1) may result in more severe disease than infection with either strain alone. This phenomenon is important because it may facilitate the identification of virulence genes through the transfer of virulence determinants between complementing strains, and it may pose a problem in the use of attenuated HSV strains for vaccines and gene delivery vectors. In this study, we have compared the percentage of recombinants present… CONTINUE READING