Recombinant vascular endothelial growth factor 121 infusion lowers blood pressure and improves renal function in rats with placentalischemia-induced hypertension.

@article{Gilbert2010RecombinantVE,
  title={Recombinant vascular endothelial growth factor 121 infusion lowers blood pressure and improves renal function in rats with placentalischemia-induced hypertension.},
  author={Jeffrey S. Gilbert and Joseph Verzwyvelt and Drew Colson and Marietta Arany and S Ananth Karumanchi and Joey P. Granger},
  journal={Hypertension},
  year={2010},
  volume={55 2},
  pages={380-5}
}
Antagonism of vascular endothelial growth factor (VEGF) signaling by soluble fms-like tyrosine kinase 1 occurs during preeclampsia and is proposed to play an important role in the pathogenesis of preeclampsia. We reported recently that hypertension associated with chronic reductions in uteroplacental perfusion pressure (RUPP) is associated with increased soluble fms-like tyrosine kinase 1 and decreased free VEGF. Whether restoration of circulating VEGF can restore renal function and chronically… CONTINUE READING