Recombinant vaccinia viruses and gene gun vectors expressing the large subunit of Schistosoma mansoni calpain used in a murine immunization-challenge model.

@article{HotaMitchell1999RecombinantVV,
  title={Recombinant vaccinia viruses and gene gun vectors expressing the large subunit of Schistosoma mansoni calpain used in a murine immunization-challenge model.},
  author={S Hota-Mitchell and M W Clarke and Ron B. Podesta and Gregory A. Dekaban},
  journal={Vaccine},
  year={1999},
  volume={17 11-12},
  pages={
          1338-54
        }
}
Schistosomiasis is a parasitic disease affecting over 200 million people every year in tropical regions of the world. Drug treatment and other existing control measures are costly and have failed to eliminate the incidence of infection, morbidity and mortality due to Schistosoma mansoni infection. Vaccination of susceptible individuals using recombinant vaccines encoding key S. mansoni antigens may be the most effective and least expensive means of controlling schistosomiasis. A candidate… CONTINUE READING

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