Recombinant vaccinia-PSA (PROSTVAC) can induce a prostate-specific immune response in androgen-modulated human prostate cancer.

@article{Sanda1999RecombinantV,
  title={Recombinant vaccinia-PSA (PROSTVAC) can induce a prostate-specific immune response in androgen-modulated human prostate cancer.},
  author={M. Sanda and D. Smith and L. Charles and C. Hwang and K. Pienta and J. Schlom and D. Mileni{\'c} and D. Panicali and J. Montie},
  journal={Urology},
  year={1999},
  volume={53 2},
  pages={
          260-6
        }
}
  • M. Sanda, D. Smith, +6 authors J. Montie
  • Published 1999
  • Medicine
  • Urology
  • OBJECTIVES Prostate cancer recurrence, evidenced by rising prostate-specific antigen (PSA) levels after radical prostatectomy, is an increasingly prevalent clinical problem in need of new treatment options. Preclinical studies have suggested that for tumors in general, settings of minimal cancer volume may be uniquely suitable for recombinant vaccine therapy targeting tumor-associated antigens. A clinical study was undertaken to evaluate the safety and biologic effects of vaccinia-PSA (PROSTVAC… CONTINUE READING
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    References

    SHOWING 1-10 OF 16 REFERENCES
    Adjuvant immunotherapy (BCG) in stage D prostate cancer.
    • 25
    Antigen expression by dendritic cells correlates with the therapeutic effectiveness of a model recombinant poxvirus tumor vaccine.
    • 172
    • PDF