Recombinant vaccines for the prevention of human papillomavirus infection and cervical cancer.

@article{Palmer2009RecombinantVF,
  title={Recombinant vaccines for the prevention of human papillomavirus infection and cervical cancer.},
  author={Kenneth E. Palmer and Alfred Bennett Jenson and J Calvin Kouokam and Amanda B. Lasnik and Shin-je Ghim},
  journal={Experimental and molecular pathology},
  year={2009},
  volume={86 3},
  pages={
          224-33
        }
}
Carcinogenic human papillomaviruses (HPVs) that cause cervical cancer preferentially infect basal, metaplastic squamous cells of the transformation zone. If infection persists, and a vegetative infection ensues, a premalignant lesion may develop with the potential to progress into an invasive squamous cell carcinoma. Papillomavirus prophylactic vaccines target the systemic immune system for induction of neutralizing antibodies that protect the basal cells against infection. Because the… CONTINUE READING
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