Recombinant vaccines against infectious hematopoietic necrosis virus: production by the Caulobacter crescentus S-layer protein secretion system and evaluation in laboratory trials.

@article{Simn2001RecombinantVA,
  title={Recombinant vaccines against infectious hematopoietic necrosis virus: production by the Caulobacter crescentus S-layer protein secretion system and evaluation in laboratory trials.},
  author={B. Sim{\'o}n and J. Nomellini and P. Chiou and W. Bing-le and J. Thornton and J. Smit and J. Leong},
  journal={Diseases of aquatic organisms},
  year={2001},
  volume={44 1},
  pages={
          17-27
        }
}
  • B. Simón, J. Nomellini, +4 authors J. Leong
  • Published 2001
  • Biology, Medicine
  • Diseases of aquatic organisms
  • We report the development of an IHNV vaccine produced by a new protein production system based on the bacterium Caulobacter crescentus. The subunit vaccines that were tested contain a 184 amino acid segment of the IHNV glycoprotein in different fusion arrangements with the C. crescentus S-layer protein. Relative percent survival of 26 to 34% was demonstrated in rainbow trout fry for a vaccine that contained the 184 amino acid segment of the IHNV glycoprotein fused to the C-terminal one-quarter… CONTINUE READING
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