Recombinant urokinase for restoration of patency in occluded central venous access devices. A double-blind, placebo-controlled trial.

@article{Haire2004RecombinantUF,
  title={Recombinant urokinase for restoration of patency in occluded central venous access devices. A double-blind, placebo-controlled trial.},
  author={William D. Haire and Steven R. Deitcher and Kathleen M. Mullane and Michael R. Jaff and Carolyn M. Firszt and Gregory Alan Schulz and Debra M Schuerr and Lewis B Schwartz and Tamyra L Mouginis and R Phillip Barton},
  journal={Thrombosis and haemostasis},
  year={2004},
  volume={92 3},
  pages={
          575-82
        }
}
The interval occlusion of central venous access devices (CVADs) remains a significant clinical problem, often requiring re-intervention for catheter exchange or replacement. The purpose of this Phase 3, multi-center, double-blinded study was to test the hypothesis that instillation of recombinant urokinase (r-UK) 5000 IU/ml is superior to placebo in restoring total catheter patency to an unselected cohort of occluded CVADs. After obtaining informed consent, adult and pediatric patients with… CONTINUE READING

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