Recombinant troponin I substitution and calcium responsiveness in skinned cardiac muscle

Abstract

Using treatment with vanadate solutions, we extracted native cardiac troponin I and troponin C (cTnI and cTnC) from skinned fibers of porcine right ventricles. These proteins were replaced by exogenously supplied TnI and TnC isoforms, thereby restoring Ca2+-dependent regulation. Force then depended on the negative logarithm of Ca2+ concentration (pCa) in a… (More)
DOI: 10.1007/s004240050077

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