Recombinant transforming growth factor beta 1 and beta 2 protect mice from acutely lethal doses of 5-fluorouracil and doxorubicin

@article{Grzegorzewski1994RecombinantTG,
  title={Recombinant transforming growth factor beta 1 and beta 2 protect mice from acutely lethal doses of 5-fluorouracil and doxorubicin},
  author={Krzysztof J. Grzegorzewski and Francis W. Ruscetti and Noriaki Usui and Giovanna Damia and Dan L. Longo and J A Carlino and Jonathan R. Keller and Robert H. Wiltrout},
  journal={The Journal of Experimental Medicine},
  year={1994},
  volume={180},
  pages={1047 - 1057}
}
Transforming growth factor beta 1 (TGF-beta 1) and TGF-beta 2 can reversibly inhibit the proliferation of hematopoietic progenitor cells in vivo, leading us to hypothesize that such quiescent progenitors might be more resistant to high doses of cell cycle active chemotherapeutic drugs, thereby allowing dose intensification of such agents. Initial studies showed that whereas administration of TGF-beta 1 or TGF-beta 2 did not prevent death in normal mice treated with high doses of 5-fluorouracil… CONTINUE READING
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