Recombinant superoxide dismutase reduces oxygen free radical concentrations in reperfused myocardium.

@article{Zweier1987RecombinantSD,
  title={Recombinant superoxide dismutase reduces oxygen free radical concentrations in reperfused myocardium.},
  author={Jay L. Zweier and Barry K Rayburn and John T. Flaherty and Myron L. Weisfeldt},
  journal={The Journal of clinical investigation},
  year={1987},
  volume={80 6},
  pages={1728-34}
}
It has been proposed that oxygen free radicals mediate damage that occurs during postischemic reperfusion. Recombinant human superoxide dismutase (r-h-SOD) has been shown to be effective at reducing reperfusion injury, but it is not known if this infused enzyme actually reduces oxygen free radical concentrations in the myocardial tissue. Electron paramagnetic resonance spectroscopy was used to directly measure the effect of r-h-SOD on free radical concentrations in the postischemic heart… CONTINUE READING