Recombinant soluble murine IL-4 receptor can inhibit or enhance IgE responses in vivo.

@article{Sato1993RecombinantSM,
  title={Recombinant soluble murine IL-4 receptor can inhibit or enhance IgE responses in vivo.},
  author={Timothy A. Sato and Michael B. Widmer and Fred D. Finkelman and Hamid Madani and Courtney Jacobs and Kenneth H. Grabstein and Charles R. Maliszewski},
  journal={Journal of immunology},
  year={1993},
  volume={150 7},
  pages={2717-23}
}
This study examines the effects of soluble IL-4R (sIL-4R) administration on IgE production in vivo by using an anti-IgD injection model. Anti-IgD-treated mice were given various doses of sIL-4R or anti-IL-4 mAb over a 3-day period and serum IgE levels were determined by ELISA on day 9. The sIL-4R inhibited IgE production by up to 85%. Anti-IL-4 mAb administration resulted in comparable levels of inhibition at considerably lower doses. The disparity in efficacy between sIL-4R and anti-IL-4 mAb… CONTINUE READING

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