Recombinant soluble form of PSGL-1 accelerates thrombolysis and prevents reocclusion in a porcine model.

@article{Kumar1999RecombinantSF,
  title={Recombinant soluble form of PSGL-1 accelerates thrombolysis and prevents reocclusion in a porcine model.},
  author={Anil Kumar and Matteo Villani and U. K. Patel and J. S. Keith and Robert G. Schaub},
  journal={Circulation},
  year={1999},
  volume={99 10},
  pages={
          1363-9
        }
}
BACKGROUND We investigated whether administration of a soluble recombinant P-selectin glycoprotein ligand-1 chimera (rPSGL-Ig) in conjunction with thrombolytic therapy would enhance thrombolysis by preventing ongoing interactions of leukocytes with platelets and the injured arterial wall. METHODS AND RESULTS An occlusive thrombus was formed in an internal iliac artery of Yorkshire pigs by placement of a copper coil in the artery under fluoroscopic guidance. Pigs then received heparin and, 15… CONTINUE READING

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