Recombinant snake venom prothrombin activators

@article{Lvgren2013RecombinantSV,
  title={Recombinant snake venom prothrombin activators},
  author={A. L{\"o}vgren},
  journal={Bioengineered},
  year={2013},
  volume={4},
  pages={153 - 157}
}
  • A. Lövgren
  • Published 2013
  • Biology, Medicine
  • Bioengineered
Three prothrombin activators; ecarin, which was originally isolated from the venom of the saw-scaled viper Echis carinatus, trocarin from the rough-scaled snake Tropidechis carinatus, and oscutarin from the Taipan snake Oxyuranus scutellatus, were expressed in mammalian cells with the purpose to obtain recombinant prothrombin activators that could be used to convert prothrombin to thrombin. We have previously reported that recombinant ecarin can efficiently generate thrombin without the need… Expand
5 Citations
Blood Coagulation Induced by Iranian Saw-Scaled Viper (Echis Carinatus) Venom: Identification, Purification and Characterization of a Prothrombin Activator
TLDR
This study showed that the fraction which separated from Iranian snake Echis carinatus venom can be a prothrombin activators, and it can be concluded that this fraction is a procoagulant factor. Expand
Progress Curve Analysis of the One Stage Chromogenic Assay for Ecarin.
TLDR
It is demonstrated here that rates of prothrombin and p-nitroaniline production can be converted to absolute thrombin concentrations using the Michaelis-Menten equation, substituted with values for kcat and Km. Expand
Snake Venoms in Drug Discovery: Valuable Therapeutic Tools for Life Saving
TLDR
An up-to-date survey on the pharmacology of snake-venom bioactive components is shown and their therapeutic perspectives against a wide range of pathophysiological conditions are evaluated. Expand
Formulation adhésive et utilisations associées
La presente invention concerne une formulation adhesive qui comprend un melange contenant un fibrinogene et un activateur exogene d'un element d'une cascade de coagulation sanguine mammifere.

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