Recombinant respiratory syncytial viruses with deletions in the NS1, NS2, SH, and M2-2 genes are attenuated in vitro and in vivo.

@article{Jin2000RecombinantRS,
  title={Recombinant respiratory syncytial viruses with deletions in the NS1, NS2, SH, and M2-2 genes are attenuated in vitro and in vivo.},
  author={Hong Jin and Helen Zhou and Xing Cheng and Roderick S. Tang and Mary Grace Mu{\~n}oz and Nick Nguyen},
  journal={Virology},
  year={2000},
  volume={273 1},
  pages={210-8}
}
Respiratory syncytial virus (RSV) encodes several proteins that lack well-defined functions; these include NS1, NS2, SH, and M2-2. Previous work has demonstrated that NS2, SH, and M2-2 can each be deleted from RSV genome and thus are considered as accessory proteins. To determine whether RSV can replicate efficiently when two or more transcriptional units are deleted, we removed NS1, NS2, SH, and M2-2 genes individually and in different combinations from an infectious cDNA clone derived from… CONTINUE READING
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