Recombinant rabies virus as potential live-viral vaccines for HIV-1.

@article{Schnell2000RecombinantRV,
  title={Recombinant rabies virus as potential live-viral vaccines for HIV-1.},
  author={Matthias J Schnell and Heather D. Foley and Catherine A. Siler and James P. McGettigan and Bernhard Dietzschold and Roger J. Pomerantz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 7},
  pages={3544-9}
}
Recombinant, replication-competent rabies virus (RV) vaccine strain-based vectors were developed expressing HIV type I (HIV-1) envelope glycoprotein (gp160) from both a laboratory-adapted (CXCR4-tropic) and a primary (dual-tropic) HIV-1 isolate. An additional transcription stop/start unit within the RV genome was used to express HIV-1 gp160 in addition to the other RV proteins. The HIV-1 gp160 protein was stably and functionally expressed, as indicated by fusion of human T cell lines after… CONTINUE READING

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